Detection of soluble alloantigen immune complexes

Details Detection of soluble alloantigen immune complexes Detection of soluble alloantigen immune complexes

G - Physics

01

N

G01N 33/566 (2006.01) G01N 33/539 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2099862

2099862 9309434 PCTABS00022 Reactivity between alloantigen and alloantigen-specific ligand, such as HLA and anti-HLA antibody, is detectable in a sample by separating from the sample a portion of a targeted class of ligands (including such ligands complexed with alloantigen) and measuring the amount of alloantigen in such complex containing fractions. In another embodiment of the invention, reactivity between a plurality of samples is detected by measuring soluble alloantigen in at least first and second biological samples and in a mixture of the samples. Since the formation of alloantigen immune-complexes in the mixture alters the physical and immunological behavior of soluble alloantigen, a divergence between the measured and expected concentration of the mixture indicates reactivity.

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