C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/34 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01) C12N 5/10 (2006.01) C12Q 1/54 (2006.01)
Patent
CA 2662507
Methods and compositions for detecting the sub-cellular localization of a molecule are provided. Aspects of the invention include detecting translocation of a cell-surface receptor to a sub-cellular compartment, e.g., the endosome, using a reduced affinity enzyme complementation reporter system. Also provided are systems and kits for use in practicing embodiments of the methods.
Cette invention concerne des procédés et des compositions permettant de détecter la position infracellulaire d'une molécule. Des aspects de cette invention comprennent la détection de la translocation d'un récepteur de surface cellulaire vers un compartiment infracellulaire, par exemple, l'endosome, au moyen d'un système rapporteur de complémentation enzymatique à affinité réduite. Cette invention concerne également des systèmes et des trousses conçus pour être utilisés pour la mise en oeuvre des procédés susmentionnés.
Blau Helen M.
Hammer Mark Morris
Wehrman Tom
Fetherstonhaugh & Co.
The Board Of Trustees Of The Leland Stanford Junior University
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