Detection of tuberculosis and infection by mycobacterium...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/02 (2006.01) G01N 33/564 (2006.01)

Patent

CA 2572383

The present invention concerns methods for in vitro detection of an infection by Mycobacterium tuberculosis in mammals, and methods for in vitro distinction between mammals infected with Mycobacterium tuberculosis in which the disease is declared (active form) and mammals which are infected but asymptomatic for tuberculosis (latent form), and a method for in vitro distinction between mammals presenting an active form of tuberculosis and mammals not infected by M tuberculosis or presenting a latent form of tuberculosis. The present invention also pertains to kits for detection and distinction between infected mammals presenting tuberculosis symptoms and infected mammals with no disease development, and a kit for distinguishing between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis.

Cette invention concerne des procédés permettant de détecter in vitro une infection par la bactérie de type Mycobacterium tuberculosis chez des mammifères, ainsi que des procédés permettant de faire la distinction in vitro entre des mammifères infectés par la bactérie de type Mycobacterium tuberculosis chez lesquels la maladie est déclarée (forme active) et des mammifères qui sont infectés la bactérie de type Mycobacterium tuberculosis mais sont asymptomatiques (forme latente). Cette invention concerne également un procédé permettant de faire la distinction in vitro entre des mammifères présentant une forme active de la tuberculose et des mammifères non infectés par la M tuberculosis ou présentant une forme latente de tuberculose. En outre, cette invention concerne des trousses permettant de détecter et de faire la distinction entre des mammifères infectés présentant des symptômes de la tuberculose et des mammifères infectés mais chez lesquels la maladie de ne développe pas; ainsi qu'une trousse permettant de faire la distinction entre des mammifères présentant une forme active de tuberculose et des mammifères non infectés par la bactérie de type M. tuberculosis ou présentant une forme latente de tuberculose.

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