G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/86 (2006.01) C12Q 1/56 (2006.01)
Patent
CA 2651230
This application concerns a process and a test for the detection of the activation of coagulation, particularly when it is responsible for venous thromboembolic diseases, using the measurement of the levels of D-dimers and soluble fibrin produced during a fibrin lysis process activated in a blood sample. The method according to the invention is based on the comparison of levels of D-dimers which corresponds to the degradation of soluble fibrin and the level of D-dimers in the sample, with normal threshold values. The test of the invention can also be used to determine if anticoagulation in a patient is sufficient.
La présente demande porte sur un procédé et un test pour la détection de l'activation de la coagulation, en particulier lorsqu'elle est responsable de maladies veineuses thromboemboliques, mettant en AEuvre le dosage des D-dimères et le dosage de la fibrine soluble produits lors d'un processus de fibrinolyse activé dans un échantillon sanguin. La méthode selon l'invention s'appuie sur la comparaison du taux de D-dimères correspondant à la dégradation de la fibrine soluble et du taux de D-dimères de l'échantillon, avec des valeurs seuils normales. Le test de l'invention peut également être utilisé pour déterminer si l'anticoagulation est suffisante chez le malade.
Mirshahi Bibi Shah Soltan
Soria Jeannette
Assistance Publique-Hopitaux de Paris
Diagnostica Stago
Smart & Biggar
LandOfFree
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