Detection systems and methods

Details Detection systems and methods Detection systems and methods

G - Physics

01

N

G01N 30/76 (2006.01) G01F 23/296 (2006.01) G01N 30/50 (2006.01)

Patent

CA 2468317

This application describes apparatus and methods using ultrasound transmitted through a chromatography column bed to determine the status of materials in the bed space, particularly during chromatography runs. Detected conditions include the profile of a band of eluting material - to see whether it is satisfactory - the arrival of a band of material at the column output, the fitness for use of the bed packing, the passage of different mobile phasese.g. salt fronts, and other conditions. Aspects claimed include control processors and corresponding programmed products.

L'invention concerne un appareil et des procédés utilisant des ultrasons transmis à travers un lit de colonne chromatographique afin de déterminer l'état de matériaux dans l'espace du lit, en particulier pendant des cycles chromatographiques. A titre d'exemple d'états détectés, on peut citer le profil d'une bande de matériau d'élution (afin de vérifier s'il est satisfaisant), l'arrivée d'une bande de matériau à la sortie de la colonne, l'aptitude d'utilisation au remplissage du lit, le passage de phases mobiles différentes, par exemple des fronts de sel, et d'autres états. Certains aspects de l'invention concernent des processeurs de commande et des produits programmés correspondants.

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