Determination of collagen genotype

Details Determination of collagen genotype Determination of collagen genotype

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2247171

Diagnostic means that determines the genotype of a collagen gene of an individual is described. A polymorphism in the collagen gene correlates with predisposition to osteoporosis, so diagnosis of a predisposition is achieved using the diagnostic means. An isolated gene comprising the nucleotide substitution of the polymorphism is also described, as is a method of diagnosis based on the presence or absence of the polymorphism.

L'invention concerne un système de diagnostic pour déterminer le génotype d'un gène du collagène d'un individu. Il existe une corrélation entre le polymorphisme du gène du collagène et la prédisposition à l'ostéoporose. Le système de l'invention permet de diagnostiquer une predisposition à l'ostéoporose. L'invention concerne également un gène isolé comprenant la substitution nucléotidique du polymorphisme et une méthode de diagnostic basée sur la présence ou l'absence de polymorphisme.

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