G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/92 (2006.01) C12Q 1/34 (2006.01) G01N 33/58 (2006.01) C07D 271/12 (2006.01)
Patent
CA 2384394
Test for determination of the integrity of complex phospholipid/lipid structures with the aid of synthetic fluorescence-labeled acylglycerides and its use for determination of the activity of lipases/lipase inhibitors. A simple continuous test for the identification of structures which favor the arrangement of aromatics to give charge-transfer complexes, such as, for example, complex phospholipid/lipid structures (bilayer, monolayer, aggregate, micelles), with the aid of synthetic fluorescence-labeled acylglycerides, and its use for determination of the activity of lipases/lipase inhibitors, is described, furthermore a monoacylglyceride for use in this test and a process for its preparation, and the substrate obtained therefrom and a process for the preparation thereof.
L'invention concerne un test continu simple destiné à l'identification de structures qui favorisent l'arrangement d'aromates en complexes de transfert de charge, tels que des structures complexes phospholipide/lipide (bicouche, monocouche, aggrégats, miscelles), à l'aide d'acylglycérides synthétiques à marquage fluorescent. L'invention concerne également l'utilisation de ce test pour déterminer l'activité de lipases/inhibiteurs de lipases. L'invention concerne enfin un monoacylglycéride utilisé dans ce test et son procédé de production ainsi que le substrat ainsi obtenu et son procédé de production.
Jordan Holger
Kleine Horst
Mueller Guenter
Petry Stefan
Wenzel Horst
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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