C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/06 (2006.01) C07F 15/00 (2006.01) C07F 17/00 (2006.01) G01N 27/26 (2006.01)
Patent
CA 2578391
Compositions and methods for electrochemical detection of nucleic acid are disclosed. The compositions comprise electrocatalytic intercalators that bind to double-stranded nucleic acid and oxidize nucleic acid. Methods of detecting nucleic acid in a sample comprise forming double-stranded nucleic acid that is bound by electrocatalytic intercalators wherein the intercalators catalyze oxidation of the nucleic acid at the surface of an electrode.
La présente invention décrit des mélanges et des méthodes permettant la détection électrochimique d~acides nucléiques. Les mélanges comprennent des espaceurs électrocatalytiques qui se lient chimiquement à un acide nucléique à double brin et oxydent ledit acide nucléique. Les méthodes d~identification d~acides nucléiques dans un échantillon comprennent la formation de liaisons entre un acide nucléique à double brin et des espaceurs électrocatalytiques, ces derniers catalysant l~oxydation de l~acide nucléique à la surface d~une électrode.
Gao Zhiqiang
Xie Fang
Xie Hong
Agency For Science Technology And Research
Blake Cassels & Graydon Llp
LandOfFree
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