Determination of responders to chemotherapy

Details Determination of responders to chemotherapy Determination of responders to chemotherapy

G - Physics

01

N

G01N 33/574 (2006.01)

Patent

CA 2605151

The present invention relates to a method of determining whether a biological sample comprising human lung cancer cells is sensitive to a combination of an epidermal growth factor receptor inhibitor and a chemotherapeutic agent by determining the overexpression of a phosphorylated AKT protein and/ or a phosphorylated MAPK protein in the biological sample. The invention is also related to methods for deriving a candidate agent or for selecting a composition for inhibiting the progression of lung cancer in a patient wherein a phosphorylated Akt protein and/ or a phosphorylated MAPK protein is used.

La présente invention concerne un procédé permettant de déterminer si un échantillon biologique comprenant des cellules cancéreuses de poumon humain est sensible à une combinaison d'un inhibiteur du récepteur du facteur de croissance épidermique et d'un agent chimiothérapique par détermination de la surexpression d'une protéine AKT et/ou MAKT phosphorylée dans l'échantillon biologique. L'invention concerne également des procédés permettant de dériver un candidat agent ou de sélectionner une composition pour bloquer la progression du cancer du poumon chez un patient, avec utilisation d'une protéine AKT et/ou MAKT phosphorylée.

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