G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) C12Q 1/68 (2006.01) G01N 33/564 (2006.01)
Patent
CA 2438757
Methods are provided for determining cartilage degeneration or regeneration in a joint tissue in a patient by measuring levels of osteogenic protein-1 (OP-1) protein and/or mRNA in synovial fluid or joint tissue. The methods according to the invention are useful for detecting, diagnosing, predicting, determining a predisposition for, or monitoring joint tissue degeneration and regeneration in a patient including inflammatory joint disease or age-related disorders.
L'invention concerne des méthodes de détermination de la dégénérescence ou de la régénération du cartilage d'un tissu articulaire chez un patient, consistant à mesurer les taux de la protéine 1 ostéogénique (OP-1) et/ou de l'ARNm dans la synovie ou le tissu articulaire en question. Selon l'invention, ces méthodes s'utilisent pour détecter, diagnostiquer, prévoir, déterminer une prédisposition pour, ou surveiller la dégénérescence et la régénération d'un tissu articulaire chez un patient souffrant d'une affection articulaire d'origine inflammatoire ou de troubles liés à l'âge.
Chubinskaya Susanna
Kuettner Klaus E.
Rueger David C.
Mbm Intellectual Property Law Llp
Rush University Medical Center
Stryker Corporation
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