Determining potency of streptococcal preparations

Details Determining potency of streptococcal preparations Determining potency of streptococcal preparations

G - Physics

01

N

167/37

G01N 33/569 (2006.01)

Patent

CA 1225587

Abstract of the Disclosure Antigenicity of streptococcal preparations useful for inducing anti-streptococcal immunity in animals can be determined using a combining power technique. Method involves incubating serial dilutions of the antigen prepar- ation with known amounts of anti-streptococcal antiserum, thereby lessening, in serial manner, the combining power of the antiserum. The serial reaction products are then incubated with serial dilutions of streptococcal prepara- tions having known activity and the effects of the serial reaction products on such activity are then determined by in vivo means. Those determinations can be related to a standard for determining potency of the streptococcal preparation. Assay technique is especially useful in determining potency of Streptococcus equi bacterins or bacterin derivatives. CL-70

444298

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