C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/1.235
C12N 15/31 (2006.01) A61K 39/10 (2006.01) C07K 14/235 (2006.01) C12N 1/20 (2006.01) C12N 1/21 (2006.01) C12N 15/63 (2006.01)
Patent
CA 1341591
A new method is described for the preparation of a safe, immunogenic and efficacious vaccine for protection against the disease pertussis. In development of this vaccine, specific functional sites of pertussis toxin have been identified, and using this information, defined mutant holotoxins have been produced by site directed mutagenesis of the toxin gene. A number of these toxin analogues are detoxified, retain an immunodominant Si epitope, are immunogenic and are protective in the standard pertussis vaccine potency test in mice.
583938
Boux Heather Anne
Cockle Stephen Anthony
Klein Michel Henri
Lossmore Sheena May
Zealey Gavin Ross
Connaught Laboratories Limited
Sanofi Pasteur Limited/sanofi Pasteur Limitee
Sim & Mcburney
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