Detoxified pneumococcal neuraminidase and uses thereof

Details Detoxified pneumococcal neuraminidase and uses thereof Detoxified pneumococcal neuraminidase and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 9/24 (2006.01) A61K 39/09 (2006.01)

Patent

CA 2688009

Provided herein are compositions designed to reduce or prevent pneuomococcal infections, nasal carriage, nasal colonization, and central nervous system invasion. Provided herein is a composition comprising a polypeptide comprising the amino acid sequence of SEQ ID NO: 19 or a variant thereof that can elicit an anti-neuraminidase immune response. Further provided are methods of making and using the compositions disclosed herein. Specifically provided are methods of generating antibodies in a subject comprising administering to the subject an agent or composition taught herein. Also provided are methods of reducing or preventing nasal carriage or pneumococcal infection in a subject comprising administering to the subject a composition taught herein.

L'invention porte sur des compositions mises au point pour réduire ou prévenir des infections pneumococciques, le portage nasal, la colonisation nasale et l'invasion du système nerveux central. L'invention porte sur une composition comprenant un polypeptide comprenant la séquence d'acides aminés SEQ ID NO : 19 ou un variant de celle-ci qui peut déclencher une réponse immunitaire anti-neuraminidase. L'invention porte également sur des procédés de fabrication et d'utilisation des compositions décrites ici. De façon spécifique, l'invention porte sur des procédés de génération d'anticorps dans un sujet comprenant l'administration au sujet d'un agent enseigné ici ou d'une composition décrite ici. L'invention porte également sur des procédés de réduction ou de prévention du portage nasal ou d'une infection pneumococcique chez un sujet comprenant l'administration audit sujet d'une composition décrite ici.

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