Deubiquitinating enzymes that regulate cell growth

Details Deubiquitinating enzymes that regulate cell growth Deubiquitinating enzymes that regulate cell growth

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/19 (2006.01) A61K 38/55 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 16/40 (2006.01) C12N 9/10 (2006.01) C12N 9/64 (2006.01) C12N 9/96 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2229204

The present invention relates to ubiquitin-specific thiol proteases or deubiquitinating enzymes, referred to as DUB (DeUBiquitinating) enzymes, of eukaryotic origin which are members of a superfamily of deubiquitinating enzymes and which comprise a new subfamily of deubiquitinating enzymes which are similar in size and amino acid sequence to one another. DUB enzymes of the present invention are of eukaryotic origin, such as vertebrate origin, including mammalian (e.g., murine, human) origin, as well as yeast origin. All DUB enzymes of the present invention are inducible by at least one cytokine.

Thiol-protéases spécifiques à l'ubiquitine ou enzymes de désubiquitination, appelées enzymes DUB, d'origine eucaryote, membres d'une superfamille d'enzymes de désubiquitination et qui comprennent une nouvelle sous-famille de telles enzymes similaires l'une à l'autre sur le plan des dimensions et de la séquence d'acides aminés. Les enzymes DUB de la présente invention sont d'origine eucaryotique, provenant par exemple de vertébrés, notamment de mammifères (souris, homme), ou de levures. Toutes les enzymes DUB visées ici peuvent être induites par au moins une cytokine.

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