A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) C12N 5/071 (2010.01) C12N 15/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2592870
This invention provides a genetically tractable in situ non-human animal model for hepatocellular carcinoma. The model is useful, inter alia, in understanding the molecular mechanisms of liver cancer, in understanding the genetic alterations that lead to chemoresistance or poor prognosis, and in identifying and evaluating new therapies against hepatocellular carcinomas. The liver cancer model of this invention is made by altering hepatocytes to increase oncogene expression, to reduce tumor suppressor gene expression or both and by transplanting the resulting hepatocytes into a recipient non-human animal.
L'invention concerne un modèle animal non humain pouvant être traité génétiquement in situ pour l'hépatocarcinome. Le modèle est utile, entre autres, pour comprendre les mécanismes moléculaires du cancer du foie, pour comprendre les modifications génétiques qui entraînent une chimiorésistance ou un pronostic pauvre et pour identifier et évaluer de nouvelles thérapies contre l'hépatocarcinome. Pour obtenir le modèle pour le cancer du foie selon l'invention, on modifie des hépatocytes afin de renforcer l'expression oncogène, de réduire l'expression génétique ou les deux et on transplante les hépatocytes obtenus dans un animal non humain receveur.
Lowe Scott W.
Spector Mona S.
Zender Lars
Cold Spring Harbor Laboratory
Smart & Biggar
LandOfFree
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