Development and use of fluorescent probes of unbound analytes

Details Development and use of fluorescent probes of unbound analytes Development and use of fluorescent probes of unbound analytes

G - Physics

01

N

G01N 33/58 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2556221

A method for high throughput screening of probes is described. These probes are useful for characterization and measurement of unbound metabolites in a fluid sample, particularly characterization and measurement of levels of unbound free fatty acids. By practice of the disclosed invention, a profile of unbound metabolites can be determined for an individual which can be used to determine the individual's relative risk for disease such as stroke, cardiac disease and cancer.

L'invention a trait à un procédé de criblage à haut rendement de sondes. Lesdites sondes sont utiles pour caractériser et mesurer des métabolites non liés dans un échantillon de fluide, en particulier pour caractériser et mesurer les niveaux d'acides gras libres non liés. La mise en oeuvre de la présente invention permet de déterminer un profil de métabolites non liés pour un sujet, ledit profil pouvant servir à déterminer le risque relatif présenté par le sujet de contracter des maladies telles qu'un accident vasculaire cérébral, une maladie cardiaque ou un cancer.

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