C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 35/36 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) C07K 14/025 (2006.01) C07K 14/16 (2006.01) C07K 14/495 (2006.01) C07K 14/81 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/89 (2006.01) G01N 33/48 (2006.01)
Patent
CA 2134675
2134675 9322430 PCTABS00027 The keratin K1 vector for expression of a nucleic acid cassette in the epidermis. The vector has a 5' flanking region of the keratin K1 gene including a 5' flanking sequence, a keratin K1 promoter, 5' transcribed but untranslated region and a first intron and an intron/exon boundary, all in sequential and positional relationship for expression of a nucleic acid cassette. A 3' flanking region in the K1 keratin gene containing regulatory sequences including a 3' transcribed but untranslated region and contiguous noncoding DNA containing the transcriptional termination region. The 3' flanking region and a 5' flanking region are linked by a polylinker having a plurality of restriction endonuclease sites for the insertion of a nucleic acid cassette. The nucleic acid cassette encodes a sequence which can be used to express any protein, polypeptide or antisense RNA. The vector can be inserted both in vivo and ex vivo into epidermal cells. Further, it can be used for making transgenic animals or bioreactors of epidermal cells. The vector has been found useful for gene therapy in treatment of a variety of diseases including skin ulcers, wound healing, surgical incisions, psoriasis and cancer.
Greenhalgh David A.
Roop Dennis R.
Rothnagel Joseph A.
Yuspa Stuart H.
Baylor College Of Medicine
Smart & Biggar
The United States Of America As Represented By The Secretary Of The Dep Artment Of Health And
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