C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A61K 39/12 (2006.01) A61P 31/14 (2006.01) C12N 15/00 (2006.01) C12N 15/40 (2006.01)
Patent
CA 2661296
The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3' untranslated region (3'-UTR) comprising a .DELTA.30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the .DELTA.30 mutation deleted from the 3'-UTR that removes sequence in the 5' direction as far as the 5' boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3'-UTR of a dengue virus of a first serotype with the 3'-UTR of a dengue virus of a second serotype, optionally containing the .DELTA.30 mutation and nucleotides additional to the .DELTA.30 mutation deleted from the 3'-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus.
La présente invention concerne un virus de la dengue ou un virus de la dengue chimérique qui contient une mutation dans la région 3' non traduite (3'-UTR) comportant une mutation .DELTA.30 qui supprime la structure homologue TL-2 dans chacun des sérotypes 1, 2, 3, et 4 du virus de la dengue et des nucléotides en plus de la mutation .DELTA.30, délétés de la région 3'-UTR, qui suppriment la séquence dans la direction 5' jusqu'à la limite 5' de la structure homologue TL-3 dans chacun des sérotypes 1, 2, 3, et 4 du virus de la dengue, ou un remplacement de la région 3'-UTR du virus de la dengue d'un premier sérotype avec la région 3'-UTR d'un virus de la dengue d'un second sérotype, contenant éventuellement la mutation .DELTA.30 et des nucléotides en plus de la mutation .DELTA.30, délétés de la région 3'-UTR. L'invention concerne également des compositions immunogènes, des procédés permettant d'induire une réponse immune, et des procédés de production d'un virus de la dengue ou d'un virus de la dengue chimérique.
Blaney Joseph E.
Murphy Brian R.
Whitehead Stephen S.
Department Of Health And Human Services The Government Of The United States Of America As Represented By
Sim & Mcburney
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