Development of molecular imaging probes for carbonic...

Details Development of molecular imaging probes for carbonic... Development of molecular imaging probes for carbonic...

C - Chemistry, Metallurgy

07

D

C07D 249/04 (2006.01) A61K 31/4192 (2006.01) A61P 35/00 (2006.01) C07D 249/06 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) G01N 33/532 (2006.01)

Patent

CA 2683434

The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.

Cette invention concerne des procédés permettant d'identifier des inhibiteurs avec une affinité de liaison élevée pour l'enzyme anhydrase-IX carbonique (CA-IX) au moyen de la chimie clic. Ces procédés consistent à utiliser les candidats de cette enzyme en tant qu'agents d'imagerie par tomographie par émission de positrons (PET).

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