C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0783 (2010.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61K 38/20 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2319666
A population of mammalian T-cells enriched in cells which have a cytokine production profile characteristic of Th2-like cells (IL-4 production, etc.) is produced by culturing T-cells, including thymocytes, in a conditioned medium (CM), which is prepared by culturing mammalian cells such as peripheral blood cells in the presence of plant mitogens. The proliferation and differentiation to single positive T-cells is promoted by the presence of IL-4 in the culture medium. The enriched population of IL-4 producing T-cells according to the invention show potential use as a source of cells for cell therapy in treating IL-4 response related disorders including certain autoimmune conditions such as diabetes mellitus.
On produit une population de cellules T mammaliennes enrichies dans des cellules dotées d'un profil de production de cytokine caractéristique des cellules de type Th2 (production d'IL-4, etc.) en cultivant des cellules T, y compris des lymphocytes thymiques, dans un milieu conditionné (CM), préparé par culture de cellules mammaliennes telles que des cellules du sang périphérique en présence de mitogènes végétaux. La prolifération et la différenciation vers des cellules T positives uniques est favorisée par la présence de l'IL-4 dans le milieu de culture. La population enrichie de cellules T produisant l'IL-4 présente un potentiel d'utilisation en tant que source de cellules dans le cadre d'une cytothérapie concernant des affections liées à une réaction à l'IL-4, notamment certains états auto-immuns comme le diabète sucré.
Bell David
Delovitch Terry
Gao Jian-Xin
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hemosol Inc.
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