A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) A61K 49/00 (2006.01) C07K 14/47 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2458193
Alzheimer's disease, Parkinson's disease and Lewy body disease are the most commonly found neurodegenerative disorders in the elderly. The invention is a transgenic mouse that contains two transgenes, human .alpha.-synuclein and human amyloid precursor protein, which are responsible for the formation of the neuritic plaques, Lewy bodies and neurodegeneration seen in the above mentioned diseases. The transgenic mouse is an accurate model for disease by both functional and pathological assays.
La maladie d'Alzheimer, la maladie de Parkinson et la maladie des corps de Lewy sont les troubles neurodégénératifs les plus fréquents chez les personnes âgées. L'invention porte sur une souris transgénique à deux transgènes: la .alpha.-synucléine humaine et la protéine humaine précurseur de l'amyloïde qui sont responsables de la formation des plaques névritiques, des corps de Lewy et de la neurodégénérescence apparaissant dans les susdites maladies. La souris transgénique constitue un modèle précis de ces maladies utilisable dans des essais fonctionnels et pathologiques.
Mallory Margaret E.
Masliah Eliezer
Rockenstein Edward
Smart & Biggar
The Regents Of The University Of California
LandOfFree
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