Developmental animal model of temporal lobe epilepsy

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/00 (2006.01) A01K 67/027 (2006.01) A01N 37/12 (2006.01) A61K 31/198 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2448647

Disclosed is a developmental animal model of temporal lobe epilepsy and other seizures-related disorders. In particular, the invention provides a method of inducing a permanent change in the neurological development of a rodent, such as a rat, comprising daily administration of low doses of a kainate receptor agonist to the animal in the second postnatal week, wherein after treatment with the kainate receptor agonist the animal exhibits reproducible seizure-like symptoms when exposed to mild to moderate stressors. Rats treated using the above method are particularly useful as a non-human system for studying temporal lobe epilepsy, as well as for studying the efficacy of potential anti- epileptic compounds and pharmaceutical preparations.

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