Device and method for detecting and localizing cells by...

G - Physics – 01 – N

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G01N 21/63 (2006.01) G01N 21/64 (2006.01) G01N 21/77 (2006.01)

Patent

CA 2397943

The present invention provides devices and methods for detection of particles, such as biological cells (115), in samples using a photosensitive waveguide (100). The photosensitive waveguide (100) changes its transmissivity in a detectable manner in response to controlling radiation (130) emitted from the particles. In preferred embodiments, the waveguide (100) is two-dimensional and the position of the particles as well as their presence is obtained by scanning the waveguide (100) in two non-parallel directions. The provided devices are preferably used to locate labeled cells (118). The present invention also includes control systems and methods for detecting and locating cells using the devices provided.

La présente invention concerne des dispositifs et des techniques permettant de détecter des particules, telles que des cellules (115) biologiques, dans des échantillons par utilisation d'un guide d'onde (100) photosensible. Ce guide d'onde (100) photosensible modifie sa capacité de transmission d'une manière que l'on peut détecter en réponse à la commande du rayonnement (130) émis en provenance de ces particules. Dans des modes préférés de réalisation de l'invention, ce guide d'onde (100) est bidimensionnel et on obtient la position des particules, de même qu'on détecte leur présence en balayant ce guide d'onde (100) dans deux directions non parallèles. Ces dispositifs sont utilisés de préférence pour localiser des cellules marquées (118). Cette invention concerne aussi des systèmes de commande et des techniques permettant de détecter et de localiser des cellules à l'aide de ces dispositifs.

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