Device and method for drug evaluation and local treatment

A - Human Necessities – 61 – M

Patent

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A61M 31/00 (2006.01) A61B 5/00 (2006.01) A61M 37/00 (2006.01)

Patent

CA 2734778

Described here are devices, systems, and kits for delivering substances to tissues. The devices generally include one or more chambers (102) and a reservoir (108) within each chamber. The reservoir may locally deliver a microdose amount of a substance to a target tissue. In some variations, a microdose amount is used in early human studies, e.g., before a phase I clinical trial, to evaluate the effect of the substance on a target tissue, or to obtain pharmacokinetic or metabolic data. In other variations, a microdose amount is used to locally treat a medical condition. In yet other variations, a microdose amount is used to locally deliver a contrast agent for a structural or functional imaging procedure. Methods for delivering and retrieving the devices from the target tissue are also described.

L'invention concerne des dispositifs, des systèmes et des nécessaires pour administrer des substances à des tissus. Les dispositifs comprennent généralement un ou plusieurs compartiments et un réservoir à l'intérieur de chaque compartiment. Le réservoir peut administrer localement une quantité de l'ordre de la microdose d'une substance à un tissu cible. Dans certaines variantes, une microdose est utilisée dans des études préliminaires sur l'homme, par exemple avant un essai clinique de phase I, afin d'évaluer l'effet de la substance sur un tissu cible, ou d'obtenir des données pharmacocinétiques ou métaboliques. Dans d'autres variantes, une microdose est utilisée pour traiter localement un état médical. Dans d'autres variantes encore, une microdose est utilisée pour administrer localement un agent de contraste pour un protocole d'imagerie structurale ou fonctionnelle. L'invention concerne également des procédés pour poser et retirer les dispositifs dans le tissu cible.

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