A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 1/02 (2006.01) C12M 1/00 (2006.01) C12Q 1/02 (2006.01) G01N 25/10 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/554 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2503203
A device for monitoring leukocyte migration is provided. The invention also provides a method of using the device to monitor leukocyte migration in the presence of physiological shear flow and therefore simulate physiological conditions of a blood vessel in vivo. The invention further provides a method of using the device to high-throughput screen a plurality of test agents. The present invention further provides a flexible assay system and numerous assays that can be used to test biological interactions and systems. Laminar flow gradients are employed mimic gradient situations present in vivo.
L'invention concerne un dispositif utilisé pour surveiller la migration des leucocytes, ainsi qu'un procédé d'utilisation de ce dispositif pour surveiller la migration des leucocytes en présence d'un flux de cisaillement physiologique et donc pour simuler les conditions physiologiques d'un vaisseau sanguin in vivo. L'invention concerne également un procédé d'utilisation de ce dispositif pour le criblage à haut débit d'une pluralité d'agents de test. De plus, l'invention concerne un système d'essai flexible et de nombreux essais pouvant être utilisés pour tester des interactions biologiques et des systèmes. Des gradients de flux laminaires sont utilisés pour reproduire des situations de gradient existant in vivo.
Kim Enoch
Kirk Gregory L.
Ostuni Emanuele
Schueller Olivier
Sweetnam Paul
Borden Ladner Gervais Llp
Surface Logix Inc.
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