Device and method for single-needle in vivo electroporation

Details Device and method for single-needle in vivo electroporation Device and method for single-needle in vivo electroporation

A - Human Necessities

61

N

A61N 1/32 (2006.01) A61M 5/00 (2006.01)

Patent

CA 2686855

Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single-needle electrode which provides for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue.

L'invention concerne un dispositif et un procédé d'administration de molécules à un tissu in vivo pour diverses applications médicales. Le dispositif comporte une électrode à aiguille unique qui permet, quand l'aiguille est insérée dans un tissu comme de la peau ou un muscle, de transmettre une impulsion au tissu avec un champ électrique non uniforme suffisant pour causer une poration réversible des cellules situées tout au long ou à proximité immédiate du tracé réalisé par l'aiguille lors de son insertion dans le tissu.

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