Device and method for treatment of dysmenorrhea

Details Device and method for treatment of dysmenorrhea Device and method for treatment of dysmenorrhea

A - Human Necessities

61

K

A61K 31/407 (2006.01) A61K 9/02 (2006.01) A61K 9/08 (2006.01) A61K 31/192 (2006.01) A61K 31/21 (2006.01) A61K 31/277 (2006.01) A61K 31/405 (2006.01) A61P 15/00 (2006.01) A61F 6/06 (2006.01) A61F 6/08 (2006.01) A61F 13/20 (2006.01) A61M 31/00 (2006.01) A61M 37/00 (2006.01)

Patent

CA 2293346

Methods, devices, and compositions for treatment of dysmenorrhea comprise an intravaginal drug delivery system containing an appropriate pharmaceutical agent incorporated into a pharmaceutically acceptable carrier whereby the pharmaceutical agent is released into the vagina and absorbed through the vaginal mucosa to provide relief of dysmenorrhea. The drug delivery system can be a tampon device (42), vaginal ring, pessary, tablet, suppository, vaginal sponge, bioadhesive tablet, bioadhesive microparticle, cream lotion, foam, ointment, paste solution, or gel. The system delivers a higher concentration to the muscle of the uterus, the primary site for the dyskinetic muscle contraction, which is the pathophysiologic cause of dysmenorrhea.

L'invention concerne des procédés, des dispositifs et des compositions de traitement de la dysménorrhée, lesquels comprennent un dispositif de libération intravaginale de médicaments renfermant un agent pharmaceutique approprié incorporé dans un excipient pharmaceutiquement acceptable. L'agent pharmaceutique est libéré dans le vagin et absorbé par les muqueuses vaginales de manière à soulager les douleurs dysménorrhéiques. Le dispositif de libération intravaginale de médicaments peut être un dispositif de type tampon (42), un anneau vaginal, un pessaire, un comprimé, un ovule, une éponge vaginale, un comprimé bioadhésif, une microparticule bioadhésive, une crème, une mousse, une pommade, une solution pâteuse ou un gel. Le système libère une concentration de médicaments élevée au niveau du muscle de l'utérus, site principal des contractions musculaires dyskinétiques qui sont la cause pathophysiologique de la dysménorrhée.

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