Device and methods for directed synthesis of chemical libraries

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/00 (2006.01) B01J 19/00 (2006.01) C07B 61/00 (2006.01) C07K 1/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/546 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2466164

The invention features a sort computer which interfaces with a sorting device in order to control the sorting of beads on a bead by bead basis. The invention further features novel methods for the directed synthesis of encoded libraries of oligomers, e.g., oligonucleotides, on beads. These methods allow the synthesis of libraries that are sufficiently large to permit complex genomic analyses to be carried out. New methods of using the encoded libraries also are described.

L'invention se rapporte à un ordinateur de tri qui est en interface avec un dispositif de tri afin de contrôler le tri des billes bille par bille. Cette invention concerne aussi de nouveaux procédés de synthèse dirigée de bibliothèques codées d'oligomères, par exemple des oligonucléotides, sur des billes. Ces procédés servent à la synthèse de bibliothèques qui sont suffisamment importantes pour permettre d'effectuer des analyses génomiques complexes. L'invention porte aussi sur de nouveaux procédés d'utilisation des bibliothèques codées.

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