C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
182/1, 167/104,
C12N 5/08 (2006.01) A61K 35/12 (2006.01) A61M 1/36 (2006.01) C07K 17/08 (2006.01) C12N 5/00 (2006.01) G01N 33/545 (2006.01)
Patent
CA 1337644
A method is provided for protecting a polymeric surface from degradation when subjected to ionizing radiation. The surface has a biologically active agent coupled thereto. The method involves applying a protective composition containing a surface- stabilizing agent and an oxygen-radical scavenger to preserve the activity of the biologically active agent coupled to the surface when the surface is subjected to sterilizing amounts of radiation. The surface- stabilizing agent is a high molecular weight agent such as is conventionally used in drying biologically active substances. The oxygen-radical scavenger is generally a polyol or a polyol moiety such as is provided by a saccharide. A polymeric surface prepared by the method of this invention and a method to conduct extra-corporeal treatment of body fluid is also provided.
616896
Lamons Donald
Okarma Thomas B.
Okrongly David A.
Fetherstonhaugh & Co.
Rorer Pharmaceutical Products Inc.
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