A - Human Necessities – 61 – M
Patent
A - Human Necessities
61
M
A61M 1/34 (2006.01) A61M 1/36 (2006.01) B01D 39/16 (2006.01) B01D 67/00 (2006.01)
Patent
CA 2180328
Filters (hollow fibers, flat-sheet membranes or depth filters) for removing leukocytes and viral inactivating agents from whole blood or blood fractions are disclosed. One type of depth filter comprises a laid textile web which has been modified to attach a ligand for viral inactivating agents, a ligand for leukocytes, or ligands for both. An exemplary membrane comprises a polyethersulfone membrane that has been similarly modified. Filter devices for simultaneously removing leukocytes and viral inactivating agents from whole blood or blood fractions are also disclosed. One type of device comprises (1) a housing surrounding (2) activated carbon and (3) a mechanically stable polymeric material which may optionally be modified to attach a ligand for leukocytes. General methods for removing leukocytes and rival inactivating agents from blood are also disclosed.
L'invention a pour objet des filtres (fibres creuses, membranes à feuille plane ou filtres en profondeur) destinés à retirer du sang total ou de fractions sanguines des leucocytes et des agents viraux inactivants. Un type de filtre en profondeur comprend une bande textile, modifiée pour fixer un ligand destiné aux agents viraux inactivants, un ligand destinés aux leucocytes, ou bien des ligands destinés aux deux. Un exemple de membrane comprend une membrane de sulfone de polyéther modifiée de façon similaire. L'invention décrit également des dispositifs filtrants destinés à retirer du sang total ou de fractions sanguines des leucocytes et des agents viraux inactivants. Un type de dispositif comprend une gaine (1) enveloppant du charbon actif (2) et un matériau polymère mécaniquement stable (3) pouvant éventuellement être modifié pour fixer un ligand destiné aux leucocytes. L'invention décrit en outre des procédés généraux pour retirer du sang des leucocytes et des agents viraux inactivants.
Azad Abdul R. M.
Castino Franco
Fouron Yves
Lee Eric Kin-Lam
Zepp Charles M.
Cassan Maclean
Hemasure Inc.
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