Device for administering an active agent to the skin or mucosa

Details Device for administering an active agent to the skin or mucosa Device for administering an active agent to the skin or mucosa

A - Human Necessities

61

M

A61M 37/00 (2006.01) A61K 9/70 (2006.01)

Patent

CA 2053272

A transdermal drug delivery device (11) comprising a drug formulation-containing reservoir (13) defined by a backing layer (12) and a drug-permeable membrane layer (16), a peelable inner liner (20) that underlies the reservoir and a portion of the backing/ membrane outwardly of the reservoir periphery, an adhesive layer (15) that underlies the inner liner and outwardly extending portions of the membrane/backing layers, and a peelable release liner layer (17) that underlies the adhesive layer with a first permanent heat seal (18) between the backing and the membrane about the perimeter of the reservoir and another peelable (impermanent) heat seal (19) between the membrane and the inner liner underlying the first permanent heat seal, the heat seals and peelable barrier layer providing barriers that isolate the drug formulation from the adhesive.

Dispositif d'administration transdermique de médicaments (11) comprenant : un réservoir (13) contenant une formulation pharmaceutique défini par une couche dorsale (12) et une membrane perméable aux médicaments (16); une couche interne pelable (20) sous-jacente au réservoir et à une partie de la couche dorsale/membrane se trouvant à l'extérieur de la périphérie du réservoir; une couche adhésive (15) sous-jacente à la couche interne et aux parties de la couche dorsale/membrane qui se prolongent vers l'extérieur; et une doublure à libération pelable (17) sous-jacente à la couche adhésive par un premier sceau thermique permanent (18) entre la couche dorsale et la membrane, autour du périmètre du réservoir, et par un autre sceau thermique pelable (non permanent) (19) entre la membrane et la couche interne sous-jacente au premier sceau. Les sceaux thermiques et la couche imperméabilisante pelable font office de barrières qui isolent la formulation pharmaceutique de l'adhésif.

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