Device for aerosolized delivery of peptide drugs

A - Human Necessities – 61 – M

Patent

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Details

A61M 15/00 (2006.01) A61J 7/00 (2006.01) A61J 7/04 (2006.01) A61M 16/00 (2006.01) A61M 16/10 (2006.01)

Patent

CA 2203257

A method of treating human patients is provided by the intrapulmonary delivery of a pharmaceutically active peptide formulation (5). The formulation is automatically released in an aerosolized form from a hand-held, self- contained, portable device (40) comprised of a means (23) for automatically releasing a measured amount of drug into the inspiratory flow path (29) of a patient in response to information obtained from a means (37) for measuring the inspiratory flow rate and determining the inspiratory volume of a patient. Reproducible dosing is obtained by providing for automatic release at the same inspiratory flow rate and inspiratory volume each time drug is released. The device includes a timer to enable a patient to take a drug at the same time each day. Further, overadministration of hormone formulation is avoided by providing a pre-programmed microprocessor (26) designed to avoid overdosing.

L'administration intrapulmonaire d'une composition peptidique (5) active du point de vue pharmaceutique constitue un procédé de traitement des patients humains. La composition est libérée automatiquement, sous forme d'aérosol, par un appareil portatif (40) indépendant et tenu à la main. Il comporte un moyen (23) destiné à libérer automatiquement une quantité dosée d'un médicament dans les voies respiratoires (29) d'un patient en réaction à des informations reçues d'un moyen (37) de mesure du débit d'air inspiré, qui détermine le volume inspiratoire de ce patient. On obtient un dosage reproductible en faisant en sorte qu'il y ait libération automatique avec le même débit d'inspiration et le même volume inspiré chaque fois qu'un dose de médicament est libérée. L'appareil comprend un programmateur pour permettre au patient de prendre un remède chaque jour à la même heure. En outre, on évite l'administration d'une dose excessive d'une composition à base d'hormone en montant un microprocesseur (26) programmé à l'avance et conçu pour éviter les doses excessives.

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