Device for enhanced delivery of biologically active...

A - Human Necessities – 61 – N

Patent

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A61N 1/30 (2006.01)

Patent

CA 2238055

A device to enhance the delivery of a drug or other substance of interest into a selected organ or tissue, comprising special electrodes, one of the electrodes carrying a container with the selected drug or other substance of interest, said electrodes being capable of being positioned at preselected locations of said organ or tissue, wherein the electrodes are all connected with a selected energy source which generates and maintains an energy field before and during the enhanced delivery of said substance, under the influence of which delivery is accomplished in a direction from the active to the passive electrode and into said organ or tissue. The energy source may be selected from suitable sources providing an electric field, a magnetic field, ultrasonic waves, high energy waves like laser beams, or a combination thereof. Further a method for the enhanced delivery of said drug or other substance of interest to an internal organ or target tissue of an organism, for example the brain, bypassing the blood-brain barrier, is disclosed.

L'invention concerne un dispositif pour améliorer l'administration d'un médicament ou de toute autre substance souhaitée à un organe ou tissu choisi, comprenant des électrodes spéciales, une de ces électrodes portant un récipient avec le médicament choisi ou une autre substance souhaitée, ces électrodes pouvant être placées à des emplacements prédéterminés de l'organe ou du tissu en question. Ces électrodes sont toutes connectées à une source d'énergie sélectionnée qui produit et entretient un champ d'énergie avant et durant l'administration accrue de cette substance et qui assure le transport de la substance dans la direction depuis l'électrode active vers l'électrode passive et dans l'organe ou le tissu. La source d'énergie peut être choisie de toute manière appropriée et elle peut émettre un champ électrique, un champ magnétique, des ondes ultrasoniques, des ondes haute énergie, telles que des faisceaux laser ou une combinaison de ceux-ci. En outre, l'invention concerne un procédé pour une administration accrue d'un médicament ou d'une autre substance souhaitée vers un organe ou un tissu interne cible d'un organisme, par exemple le cerveau, en court-circuitant la barrière hémato-encéphalique.

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