A - Human Necessities – 61 – B
Patent
A - Human Necessities
61
B
A61B 10/00 (2006.01) A61B 17/20 (2006.01)
Patent
CA 2394171
A transdermal agent sampling device (10, 120) is provided. The sampling device (10, 120) is comprised of a microblade array (2, 2') and a device (11, 12, 20, 122) for applying a partial vacuum. The microblade array (2, 2') comprises a sheet (6) having a plurality of microblades (4) for piercing the skin to a very shallow depth (i.e., 25 µm to 400 µm) to create microslits in the outermost stratum corneum layer of the skin. The partial vacuum applying device (11, 12, 20, 122) applies a partial vacuum in the range of about 0.1. to about 0.8 atm, and preferably about 0.3. to about 0.7 atm, for sampling a body analyte such as glucose in interstitial fluid. The partial vacuum is applied for a period of about 2 to about 30 seconds, and preferably about 5 to about 15 seconds. The interstial fluid is analyzed for body analyte (e.g., glucose) content or concentration.
L'invention concerne un dispositif d'échantillonnage transdermique (10, 120) de substances. Le dispositif d'échantillonnage (10, 120) comprend un réseau de microlames (2, 2') et un dispositif (11, 12, 20, 122) permettant d'appliquer un vide partiel. Le réseau de microlames (2, 2') est constitué d'une feuille (6) possédant de nombreuses microlames (4) destinées à percer la peau sur une profondeur très faible (par exemple de 25 µm à 400 µm) afin de créer des microfentes dans la couche la plus extérieure dustratum corneum de la peau. Le dispositif d'application de vide partiel (11, 12, 20, 122) permet d'appliquer un vide compris entre 0,1 atm environ et 0,8 atm environ, et de préférence entre 0,3 atm environ et 0,7 atm environ, dans le but d'échantillonner un analyte corporel dans le fluide interstitiel, tel que du glucose. Le vide partiel est appliqué entre 2 secondes environ et 30 secondes environ, et de préférence entre 5 secondes environ et 15 secondes environ. On analyse la teneur ou la concentration en analyte corporel (par exemple, le glucose) dans le fluide interstitiel.
Cormier Michel J. N.
Lin Weiqi
Theewes Felix
Alza Corporation
Smart & Biggar
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