A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/00 (2006.01) A61F 2/30 (2006.01) A61L 27/32 (2006.01) A61L 27/54 (2006.01) A61F 2/00 (2006.01)
Patent
CA 2205104
The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipis, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process comprising subjecting a substrate to a surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm and subjecting the roughened surface to precipitation of calcium phosphate from a solution containing calcium and phosphate ions with optional coprepitation of the biologically active substance.
Dispositif implantable recouvert d'une couche de phosphate de calcium et, au choix, d'une ou de plusieurs des substances actives biologiques suivantes : facteurs de croissance, lipides, lipopolysaccharides, hormones, protéines, antibiotiques et cytostatiques. Ce dispositif résulte d'un processus de nanotechnologie qui consiste à soumettre un support à un traitement de surface jusqu'à l'obtention d'une rugosité de surface d'une distance moyenne maximum (valeur Ra) de 10 à 1 000 nm, et à soumettre cette surface rugueuse à une précipitation au phosphate de calcium à partir d'une solution contenant des ions calcium et des ions phosphate, avec facultativement, une coprécipitation de la substance active biologique.
de Bruijn Joost Dick
de Groot Klaas
Leitao Eugenia Ribeiro de Sousa Fidalgo
Wen Hai-Bo
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Chienna B.v.
Matrix Medical Holding B.v.
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