Device for optimized electrotransfer of nucleic acid vectors...

Details Device for optimized electrotransfer of nucleic acid vectors... Device for optimized electrotransfer of nucleic acid vectors...

A - Human Necessities

61

N

A61N 1/32 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2295029

This invention is directed to systems and devices that provide for remarkable enhancement of in vivo transfer into cells, particularly muscle cells and tumor cells, of nucleic acid vectors using weak electric fields, to increase the efficiency of such transfers. The devices of the invention are designed to provide an optimum voltage gradient to enhance migration of nucleic acid vectors into cells, without damaging the cells or tissue. Such devices are characterized by unique arrangements of electrodes, and by unique power limits defined by maximum voltage settings.

Cette invention concerne des systèmes et des dispositifs permettant d'améliorer de manière significative le transfert in vivo de vecteurs d'acides nucléiques dans des cellules, en particulier des cellules musculaires et des cellules tumorales et ce, grâce à des champs électriques faibles destinés à accroître l'efficacité de tels transferts. Les dispositifs selon l'invention sont conçus pour assurer un gradient de tension optimal destiné à améliorer la migration de vecteurs d'acides nucléiques dans des cellules et ce, sans abîmer les cellules ou les tissus. De tels dispositifs sont caractérisés par des agencements uniques d'électrodes et par des limites de puissance uniques définies par des réglages sur des valeurs de tension maximales.

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