Device for packing chromatographic stationary phases

G - Physics – 01 – N

Patent

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Details

G01N 30/56 (2006.01) B01D 15/08 (2006.01)

Patent

CA 2192582

Devices (10) and methods for packing a chromatography column with a continuous stationary phase. The preferred device (10) includes a brace member (11) with an engagement surface (12). The brace member (11) defines a thru-hole (13) at a location so that a passageway defined through the column is aligned with the thru-hole (13) of the brace member (11) when a first end of the column is engaged with the engagement surface (12) of the brace member (11). A funnel member engageable with an end of the column opposite the first end. The funnel member has converging walls configured to radially compress the continuous stationary phase for entry into the passageway of the column when the continuous stationary phase is pulled through the funnel member. The device (10) includes a mechanism for applying mechanical force (45) to pull the rolled continuous stationary phase through the funnel member wherein the stationary phase is radially compressed and enters the passageway of the column.

Dispositifs (10) et procédés servant à garnir une colonne de chromatographie avec une phase fixe continue. Le dispositif préféré (10) comprend un élément en forme de cale (11) pourvu d'une surface de contact (12). L'élément (11) comporte un trou de passage (13) au niveau d'un emplacement permettant d'aligner ledit trou de passage (13) sur un passage défini à travers la colonne, quand une première extrémité de la colonne se trouve en contact avec la surface (12) dudit élément (11). Un élément en forme d'entonnoir peut s'accoupler à une extrémité de la colonne opposée à la première extrémité. L'élément en forme d'entonnoir possède des parois convergentes conçues pour comprimer radialement la phase fixe continue, de façon à l'introduire dans le passage de la colonne, quand on tire ladite phase fixe à travers ledit élément en entonnoir. Le dispositif (10) comprend un mécanisme servant à exercer une force mécanique (45), de manière à tirer la phase fixe continue enroulée dans l'élément en forme d'entonnoir, dans lequel ladite phase fixe est comprimée radialement et pénètre dans le passage de la colonne.

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