Device for the delivery of bioactive agents and a method of...

A - Human Necessities – 61 – F

Patent

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A61F 2/06 (2006.01)

Patent

CA 2577855

The present invention consists of an implantable structural element for in vivo controlled delivery of bioactive active agents to a situs in a body. The implantable structural element may be configured as an implantable prosthesis, such as an endoluminal stent, cardiac valve, osteal implant or the like, which serves a dual function of being prosthetic and a carrier for a bioactive agent. Control over elution of the bioactive agents occurs through a plurality of cantilever-like cover members which prevent drug elution until an endogenous or exogenous stimulus causes the cover members to open and permit drug elution.

L'invention concerne un élément structural implantable d'administration in vivo d'agents bioactifs dans un endroit du corps. Cet élément peut être configuré comme une prothèse implantable, telle qu'un stent endoluminal, une valvule cardiaque, un implant osseux ou similaire, qui possède deux fonctions, à savoir celle d'une prothèse et d'un véhicule pour un agent bioactif. La suppression de l'élution des agents bioactifs est assurée par des éléments de couverture en porte-à-faux qui empêchent l'élution jusqu'à ce qu'un stimulus endogène ou exogène induise l'ouverture des éléments de couverture et l'élution du médicament.

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