Device for the transdermal administration of melatonin

Details Device for the transdermal administration of melatonin Device for the transdermal administration of melatonin

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 9/70 (2006.01) A61K 47/14 (2006.01)

Patent

CA 2116036

2116036 9307870 PCTABS00021 The present invention is directed to the transdermal administration of melatonin together with a suitable permeation enhancer. The invention includes a transdermal drug delivery device (10) comprising a matrix (12) adapted to be placed in melatonin- and permeation enhancer-transmitting relation with the skin site (18). The matrix (12) contains sufficient amounts of a permeation enhancer and of melatonin, in combination, to continuously administer to the skin (18) for a predetermined period of time the melatonin to provide an effective therapeutic result. The invention is also directed to a method for the transdermal administration of a therapeutically effective amount of melatonin together with a skin permeation-enhancing amount of a suitable permeation enhancer. The invention further includes methods for time- and rate-patterned transdermal delivery of melatonin to simulate the natural circadian rhythmic profile of melatonin in mammals.

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