A - Human Necessities – 61 – N
Patent
A - Human Necessities
61
N
A61N 1/30 (2006.01)
Patent
CA 2219406
The invention provides an improved electrotransport drug delivery system for analgesic drugs, namely fentanyl and sufentanil. The fentanyl/sufentanil is provided as a water soluble salt (e.g., fentanyl hydrochloride) dispersed in a hydrogel formulation for use in an electrotransport device (10). In accordance with the invention, the concentration of fentanyl/sufentanil in the donor reservoir (26) solution is maintained above a predetermined minimum concentration, whereby the transdermal electrotransport flux of fentanyl/sufentanil is maintained independent of the concentration of fentanyl/sufentanil in solution.
L'invention concerne un système amélioré d'administration de médicaments par électrotransport pour des médicaments analgésiques, c'est-à-dire le fentanyl et le sufentanil. Le fentanyl/sufentanil se présente sous la forme d'un sel hydrosoluble (par exemple hydrochlorure de fentanyl) dispersé dans une formulation d'hydrogel destiné à être utilisé dans un dispositif d'électrotransport (10). Selon l'invention, la concentration de fentanyl/sufentanil dans la solution contenue dans le réservoir donneur (26) est maintenue au-dessus d'un niveau de concentration minimum prédéterminé, de manière que le flux d'électrotransport transdermique de fentanyl/sufentanil est maintenu indépendant de la concentration de fentanyl/sufentanil en solution.
Alza Corporation
Smart & Biggar
LandOfFree
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