Devices and methods for applying a mixture of two or more...

A - Human Necessities – 61 – M

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A61M 11/00 (2006.01) A61L 24/10 (2006.01) A61M 31/00 (2006.01)

Patent

CA 2271738

Novel methods and devices which provide enhanced mixing, and application of two liquid components to form a biomaterial with minimized aerosols, are achieved using airflow rates below about 1.25 liters/minute in combination with a ratio of airflow to total liquid flow of from about 150:1 up to about 1500:1. Preferably the airflow is below about 1 liter/minute, and the ratio of airflow to total liquid flow is from about 200:1 to about 1200:1. The parameters are ideally suited for the spray application of components which form a surgical sealant, e.g., a fibrin sealant. Also a part of the present invention is novel application methods for biomaterial, e.g., surgical sealant, components at liquid flows below 1.9 ml/minute, novel methods involving the mixing of such components on the exit surface of a spray tip (14), or nozzle, novel spray tips (14), biomaterial applicators, and methods for making such applicators.

L'invention concerne de nouveaux procédés et dispositifs qui confèrent un mélange amélioré, et l'application de deux composants liquides pour former un biomatériau avec des aérosols réduits, obtenu au moyen de débits d'air inférieurs à 1,25 litres/minute environ, en combinaison avec un rapport d'air sur flux total de liquide compris entre 150:1 environ et 1500:1 environ. De préférence, le débit d'air est inférieur à 1 litre/minute environ, et le rapport d'air sur flux total de liquide est compris entre 200:1 environ et 1200:1 environ. Ces paramètres conviennent idéalement pour l'application par pulvérisation de composants formant un agent de liaison chirurgical, par ex. un produit liant la fibrine. Une partie de la présente invention a également trait à de nouveaux procédés d'application pour biomatériau, par ex. un agent d'étanchéité chirurgical, des composants à débits de liquide inférieurs à 1,9 ml/minute, à de nouveaux procédés comprenant le mélange de tels composants sur la surface de sortie d'un bout de pulvérisateur (14), ou buse, à de nouvelles buses d'injection (14), à des applicateurs de biomatériau, et à des procédés de fabrication de tels applicateurs.

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