Devices and methods for delivery of bioactive agents

Details Devices and methods for delivery of bioactive agents Devices and methods for delivery of bioactive agents

A - Human Necessities

61

L

A61L 29/08 (2006.01) A61L 29/16 (2006.01)

Patent

CA 2760187

Embodiments of the invention include bioactive agent eluting devices. In an embodiment the invention includes a bioactive agent delivery device including a substrate, a hydrophilic polymer disposed on the substrate, and a substantially amorphous bioactive agent disposed on the surface of the hydrophilic polymer. In an embodiment, the invention includes a method of making a bioactive agent delivery device including depositing a hydrophilic polymer on a substrate forming a hydrophilic surface and depositing a substantially amorphous bioactive agent on the hydrophilic surface. In an embodiment, the invention includes a bioactive agent-eluting catheter including a catheter shaft and an expandable balloon disposed on the catheter shaft. Other embodiments are included herein.

Selon des modes de réalisation, l'invention concerne des dispositifs d'élution d'agent bioactif. Dans un mode de réalisation, l'invention porte sur un dispositif de distribution d'agent bioactif qui comprend un substrat, un polymère hydrophile disposé sur le substrat et un agent bioactif sensiblement amorphe disposé sur la surface du polymère hydrophile. Dans un mode de réalisation, l'invention porte sur un procédé de fabrication d'un dispositif de distribution d'agent bioactif qui comprend le dépôt d'un polymère hydrophile sur un substrat, formant une surface hydrophile, et le dépôt d'un agent bioactif sensiblement amorphe sur la surface hydrophile. Dans un mode de réalisation, l'invention porte sur un cathéter d'élution d'agent bioactif qui comprend un arbre de cathéter et un ballonnet dilatable disposé sur l'arbre de cathéter. D'autres modes de réalisation sont décrits dans la demande.

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