Devices and methods for improving vision

Details Devices and methods for improving vision Devices and methods for improving vision

A - Human Necessities

61

F

A61F 2/14 (2006.01) A61F 9/00 (2006.01) A61F 9/007 (2006.01) A61F 9/013 (2006.01) A61L 27/38 (2006.01)

Patent

CA 2498717

A corneal appliance (60) that is placed over an eye (10) has a lens body (40) and epithelial cells (70) secured over the lens body. The epithelial cells of the appliance may be derived from cultured cells, including stem cells, such as limbal stem cells, or epithelial cell lines, or may include at least a portion of the epithelium of the eye on which the appliance is placed. The corneal appliance may have a cellular attachment element between the lens body and the epithelial cells to facilitate attachment of the epithelial cells over the lens body. The corneal appliance (60) is intended to be used on a de- epithelialized eye, which may be an eye that has had the epithelium fully or partially removed. The corneal appliance may be used to improve vision. Methods of producing the corneal appliance and of improving vision are also disclosed.

L'invention concerne un appareil cornéen (60) destiné à être placé sur un oeil (10), cet appareil comprenant une lentille (40) et des cellules épithéliales (70) fixées sur cette lentille. Les cellules épithéliales de cet appareil peuvent être dérivées de cellules obtenues par culture, y compris des cellules souches, telles que des cellules souches limbiques ou de lignées cellulaires épithéliales, ou bien elles peuvent comprendre au moins une partie de l'épithélium de l'oeil sur lequel l'appareil est placé. Cet appareil cornéen peut présenter un élément de fixation cellulaire disposé entre la lentille et les cellules épithéliales pour faciliter la fixation des cellules épithéliales sur ladite lentille. L'appareil cornéen (60) est destiné à être utilisé sur un oeil ayant perdu complètement ou partiellement son épithélium. Cet appareil cornéen peut être utilisé pour améliorer la vision. L'invention concerne également des procédés de production d'un tel appareil cornéen et d'amélioration de la vision.

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