C - Chemistry – Metallurgy – 12 – M
Patent
C - Chemistry, Metallurgy
12
M
C12M 1/12 (2006.01) G01N 33/50 (2006.01) G01N 33/52 (2006.01) G01N 33/543 (2006.01) G01N 33/558 (2006.01) G01N 30/02 (2006.01) G01N 30/90 (2006.01)
Patent
CA 2217210
A device for the separation of the liquid portion of blood from the cellular components of blood comprising a pad of porous material (12) permeable to the liquid portion of blood but capable of trapping the cellular components of blood; a substrate supporting the pad (16); and means (14), attached to the pad, for facilitating the flow of the liquid portion of the blood: (i) through interstices around the trapped cellular components of the blood and (ii) from the pad of porous material. The separation of the liquid portion of blood from the cellular components of the blood occurs by flow through the pad of porous material without significant hemolysis. The device can be incorporated into a device for the performance of specific binding assays such as immunoassays. The pad of porous material can contain an agglutinating agent such as a lectin or an anti-blood cell antibody, or a carbohydrate such as mannitol. Other devices and methods for the separation of the liquid portion of blood from the cellular components of the blood are also disclosed.
L'invention porte sur un dispositif de séparation de la partie liquide du sang d'avec ses composants cellulaires comprenant: un tampon d'un matériau poreux (12) perméable à la partie liquide mais capable de piéger les composants cellulaires; un substrat portant le tampon (16) et des moyens (14) solidaires du tampon et destinés à faciliter l'écoulement de la partie liquide: (i) à travers les interstices séparant les éléments piégés, et (ii) à partir du tampon. La susdite séparation par écoulement à travers un tampon de matériau poreux s'effectue sans produire d'hémolyse significative. Le susdit dispositif peut s'incorporer à un dispositif servant à des essais spécifiques de fixation tels que des immuno-essais. Lesdits tampons peuvent contenir un agent agglutinant qui peut être de la lectine, ou un anticorps anti-hémocytes, ou un hydrate de carbone tel que du manitol. L'invention porte également sur d'autres dispositifs et procédés de séparation de la partie liquide du sang d'avec les composants cellulaires.
Jaseph Corey L.
Ruggeri Franco
Schoengold Ronald J.
Schrier Wayne H.
Macrae & Co.
Smithkline Diagnostics Inc.
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