Devices, articles, coatings, and methods for controlled...

Details Devices, articles, coatings, and methods for controlled... Devices, articles, coatings, and methods for controlled...

A - Human Necessities

61

L

A61L 15/44 (2006.01) A61F 2/00 (2006.01) A61L 27/34 (2006.01) A61L 27/54 (2006.01) A61L 29/08 (2006.01) A61L 29/16 (2006.01) A61L 31/10 (2006.01) A61L 31/16 (2006.01) C08L 33/14 (2006.01)

Patent

CA 2616959

The present invention relates to devices, articles, coatings, and methods for controlled active agent release and/or for providing a hemocompatible surface. More specifically, the present invention relates to copolymer compositions and devices, articles, and methods regarding the same for controlled active agent release. In an embodiment, the present invention includes a copolymer composition. The copolymer composition can include a copolymer and an active agent. In an embodiment, the copolymer includes an effective portion of a monomelic unit including a polar moiety. The active agent can be polar. The active agent can be charged. The active agent can be non-polar. In an embodiment, the copolymer composition includes a random copolymer. In an embodiment, the random copolymer includes butyl methacrylate-co-acrylamido- methyl-propane sulfonate copolymer, which can provide reduced platelet adhesion.

L'invention porte sur des dispositifs, articles, revêtements et procédés relatifs à la libération contrôlée d'un agent actif et/ou à créer une surface hémocompatible, et plus spécifiquement sur des compositions de copolymères et sur des dispositifs, articles, revêtements et procédés associés de libération contrôlée d'un agent actif. Dans une exécution l'invention comprend une composition comprenant un copolymère et un agent actif. Dans une exécution le copolymère comprend une unité monomélique comportant un fragment polaire, et l'agent actif peut être polaire, non polaire ou chargé. Dans une exécution, le copolymère de la composition est aléatoire et peut comporter du butyl méthacrylate-co-acrylamido-méthyl-propane sulfonate ayant un effet réducteur sur l'adhésion des plaquettes.

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