Devices for the controlled release of active substances, as...

A - Human Necessities – 61 – K

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A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/52 (2006.01)

Patent

CA 1265449

A B S T R A C T The invention relates to a device for the controlled release of one or more active ingredients to a liquid, particularly a controlled release pharmaceutical tablet obtained by compressing a mixture of two granulates in a weight ratio of 30:70 to 70:30, said granulates having particle sizes of 0.4-2.0 mm. One of the granulates, the restraining phase granulate, comprises one or more active ingredients dispersed in a matrix of an insoluble substance, and the other granulate, the housing phase granulate, comprises a soluble material and a penetration rate limiting material, one material optionally having both functions. In the compressed de- vice, the granulates form two distinct phases, each of which is continuous. The housing phase fills large continuous pores in the restraining phase. A zero-order release rate can be obtained with the devices.

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