Devices having subsurface flow and their use in diagnostic...

B - Operations – Transporting – 01 – L

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Details

B01L 3/00 (2006.01) G01N 33/52 (2006.01) G01N 33/543 (2006.01) G01N 33/558 (2006.01)

Patent

CA 2178330

The present invention is directed to improving the performance of assays using a disposable assay device which includes a porous material (20) in liquid with a capillary track 118). In particular, the capillary track (18) is used in conjunction with the solid support to direct test sample and assay reagents directly to a defined reaction site (22) on or in the porous material (20). Signal development at the reaction site (22) indicates the assay result. The present invention is also directed to the construction of a disposable assay device (10) which includes a capillary track (18). In particular, the capillary track is formed by printing a fluid insoluble material (25a), in the reverse image of the desired capillary track (18), on a film layer (23) and then capping the printed material. Alternatively, the capillary track (18) is formed by printing a fluid insoluble material, in the reverse image (30) of the desired capillary track (18), on a porous material (25b) which is then sandwiched between two film layers (23, 26). The present invention is also directed to a drop-forming means (50) which may incorporate one or more assay reagents to allow for improved sample processing and reagent addition, mixing and incubation.

L'invention vise à améliorer les performances d'opérations de titrage à l'aide d'un dispositif de titrage jetable qui comprend un matériau poreux (20) mis en communication liquide avec une voie capillaire (18). L'invention se caractérise en ce que la voie capillaire (18) est utilisée conjointement avec le support solide pour diriger les échantillons d'essai et les réactifs de titrage directement vers un site de réaction (22) défini ou dans le matériau poreux (20). Un signal produit au niveau du site de réaction (22) indique le résultat du titrage. L'invention concerne également la réalisation d'un dispositif de titrage (10) jetable comprenant une voie capillaire (18). Plus particulièrement, la voie capillaire est formée par impression d'un matériau (25a) insoluble dans les fluides, sous forme d'une image inversée de la voie capillaire (18) voulue, sur une pellicule (23), puis par recouvrement du matériau imprimé. Selon une variante, la voie capillaire (18) est formée par impression d'un matériau insoluble dans les fluides, sous forme d'image inversée (30) de la voie capillaire (18) voulue, sur un matériau poreux (25b), pris en sandwich entre deux pellicules (23, 26). L'invention concerne en outre un élément de formation de gouttes (50) pouvant comprendre un ou plusieurs réactifs de titrage afin de permettre un meilleur traitement des échantillons, ainsi que l'adjonction de réactifs, des opérations de mélange et d'incubation.

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