Dexanabinol and dexanabinol analogs regulate inflammation...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/352 (2006.01) A61K 31/35 (2006.01) A61K 31/353 (2006.01) A61K 31/4155 (2006.01) A61K 31/4178 (2006.01) A61K 31/453 (2006.01) A61K 31/4545 (2006.01)

Patent

CA 2479676

The present invention relates to pharmaceutical compositions comprising as an active ingredient non-psychotropic cannabinoid derivatives that modulate the expression of genes involved in inflammatory and immune processes. Regulating the transcription of pro and anti-inflammatory mediators has useful therapeutic application for prevention and treatment of acute and chronic inflammation, autoimmune diseases and related disorders, pain, infections, liver diseases, cardiovascular disorders, gastrointestinal disorders, disorders of the central and peripheral nervous system including neurodegenerative diseases, respiratory diseases, renal diseases, post- operative complications, tissue rejection and certain types of cancer.

L'invention concerne des compositions pharmaceutiques comprenant, en tant que principe actif, des dérivés cannabinoïdes, non psychotropes, qui modulent l'expression de gènes impliqués dans les processus immun et d'inflammation. La régulation de la transcription de médiateurs pro- et anti-inflammatoires est utile dans les applications thérapeutiques destinées à prévenir et à traiter l'inflammation aiguë et chronique, des maladies auto-immunes et des troubles associés, la douleur, des infections, des maladies hépatiques, des troubles cardio-vasculaires, gastro-intestinaux, des troubles des systèmes nerveux central et périphérique incluant des troubles neurodégénératifs, des maladies respiratoires, des maladies rénales, des complications post-opératoires, le rejet tissulaire et certains types de cancer.

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