C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/02 (2006.01) A61K 31/721 (2006.01) A61K 47/36 (2006.01)
Patent
CA 2664650
The invention relates to a dextran functionalized with at least one hydrophobic alpha-amino acid residue, wherein said alpha-amino acid is grafted or linked to the dextran by a linker arm and a function. The term ~hydrophobic amino acid residue~ is intended to mean the product of coupling between the amine of the amino acid and an acid carried by the linker arm, wherein said dextran is amphiphilic at neutral pH. In one embodiment, the hydrophobic amino acid is selected from tryptophan derivatives such as tryptophan, tryptophanol, tryptophanamide and 2-indoleethylamine, and alkali cation salts thereof. The present invention also relates to a pharmaceutical composition containing one of the dextrans according to the invention.
L'invention concerne un dextran fonctionnalisé par au moins un reste alpha amino-acide hydrophobe, ledit alpha amino-acide étant greffé ou lié au dextran par un bras de liaison et une fonction. On entend par un reste amino-acide hydrophobe le produit de couplage entre l'amine de l'amino-acide et un acide porté par le bras de liaison, ledit dextran étant amphiphile ô pH neutre. Dans un mode de réalisation, l'amino-acide hydrophobe est choisi parmi les dérivés du tryptophane, tel que le tryptophane, le tryptophanol, le tryptophanamide, le 2-indole éthylamine et leurs sels de cation alcalin. La présente invention concerne également une composition pharmaceutique contenant l'un des dextrans selon l'invention.
Soula Gerard
Soula Olivier
Soula Remi
Adocia
Benoit & Cote Associes Inc.
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