Dextran-maleic acid monoesters and hydrogels based thereon

Details Dextran-maleic acid monoesters and hydrogels based thereon Dextran-maleic acid monoesters and hydrogels based thereon

C - Chemistry, Metallurgy

08

B

C08B 37/02 (2006.01) C08J 3/24 (2006.01) C08J 3/28 (2006.01) C08L 5/02 (2006.01)

Patent

CA 2339166

Biodegradable hydrogels are formed by photocrosslinking dextran-maleic acid monoesters in which the average degree of substitution of each glucose unit of each .alpha.-D-glucopyranosyl of dextran by maleic acid ranges from 0.60 to 1.6 and which have a weight average molecular weight ranging from 40,000 to 80,000 on a dextran basis. The hydrogels at pH 7 have maximum swelling ratios ranging from 500 to 1,500 percent. The hydrogels are characterized by increase in swelling ratio as average degree of substitution increases. The hydrogels are useful, for example, for drug delivery and solubility enhancers of drugs, as protective encapsulators of viruses used in gene therapy, and for conventional uses of hydrogels.

Des hydrogels biodégradables sont formés par photoréticulation de monoesters de dextrane-acide maléique, dans lesquels le degré moyen de substitution de chaque unité de glucose de chaque alpha -D-glucopyrannosyle de dextrane par l'acide maléique se situe entre 0,60 et 1,6, et la masse moléculaire moyenne en poids varie entre 40,000 et 80,000, sur la base du dextrane. A un pH de 7, ces hydrogels présentent un taux de gonflement maximal situé entre 500 et 1500 pour cent. Ces hydrogels sont en outre caractérisés par une hausse de ce taux de gonflement qui est proportionnelle à l'augmentation du degré moyen de substitution. Ces hydrogels sont par exemple utilisés pour l'administration de médicaments, comme agents favorisant la solubilité de médicaments, comme matériau d'encapsulation protecteurs de virus utilisés en thérapie génique, ou employés comme hydrogels traditionnels.

Affiliated with

Also associated with

Rating

Dextran-maleic acid monoesters and hydrogels based thereon does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dextran-maleic acid monoesters and hydrogels based thereon, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dextran-maleic acid monoesters and hydrogels based thereon will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1380302